Driving Directions: The Southern Illinois Airport is located between Carbondale and Murphysboro in Jackson County. The Airport lies about two miles north of Illinois Route 13 on a dedicated roadway from that highway. From the west, drive three miles east of Murphysboro on Illinois Route 13 until you see the Illinois Highway sign denoting the Southern Illinois Airport. Turn left, or north, at the intersection and proceed about two miles where you will enter Airport property. From the east, drive three miles west of Carbondale on Illinois Route 13 until you see the Illinois Highway sign denoting the Southern Illinois Airport. Turn right, or north, at the intersection and proceed about two miles where you will enter Airport property. The Airport can also be accessed from U.S. Route 51. This Route runs north and south along the east side of the Airport. From either direction, you will see an Illinois Highway sign denoting the Airport. At that intersection, drive west on Airport Road approximately two miles where you will enter Airport property. Locate the Airport of the following map: